The cultivation of hyperaccumulating plants has to be optimized and improved like other crops in order to obtain economically viable yields. To do this, it is necessary to understand the nutrient needs of the plant and to compensate for the deficiencies of the soil to obtain an optimal fertilisation. A culture of Alyssum murale exports about 100 kg of nitrogen, 90 kg of calcium, 40 kg of phosphorus and potassium per hectare per year. It is therefore necessary to compensate these withdrawals from the soil by inputs (fertilizer, manure, compost).

The crop has an optimal yield when there are 4 plants per square meter in full bloom. This way, more than 10 tons of dry matter per hectare is obtained. From this biomass more than 100 kg of nickel can be extracted. It is also necessary to carefully check that there are no other species that come to settle on the plot in the earth.Today, the efforts of agronomic research to optimize agromine concern the implementation of an agro-ecological production more respectful of the environment. We try to put the crop in a rotation with leguminous species that fix the nitrogen of the atmosphere; we use the complementarity between cultures. Organic amendments (manure, compost) are used and bacteria and animals are considered to work on the soil and help plants grow better and absorb nickel.